
the hagler lab
opening september 2024
Texas A&M University Department of Chemistry
combining RNA biophysics and drug discovery
The Hagler lab takes an interdisciplinary approach—combining quantitative biophysics, chemical biology, and high-throughput genomics—to develop predictive models for the molecular behavior and biological consequences of RNA in cells.
research themes
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RNA folding thermodynamics
Predicting RNA folding in normal and diseased cells
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RNA-protein interactions
Sequence-based determinants of RNA editing
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structure-based drug design
Design and synthesis of small molecules that target RNA structures
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high-throughput drug screening
Establishing druggability through high-throughput chemical probing