the hagler lab

opening september 2024

Texas A&M University Department of Chemistry

combining RNA biophysics and drug discovery

The Hagler lab takes an interdisciplinary approach—combining quantitative biophysics, chemical biology, and high-throughput genomics—to develop predictive models for the molecular behavior and biological consequences of RNA in cells.

research themes

  • RNA folding thermodynamics

    Predicting RNA folding in normal and diseased cells

  • RNA-protein interactions

    Sequence-based determinants of RNA editing

  • structure-based drug design

    Design and synthesis of small molecules that target RNA structures

  • high-throughput drug screening

    Establishing druggability through high-throughput chemical probing